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Test Code BIOTN Biotin, Serum


Ordering Guidance


If testing for biotinidase deficiency is requested, order BIOTS / Biotinidase, Serum.



Shipping Instructions


Freeze specimens within 3 days of collection and send frozen.



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Measurement of biotin in serum

 

Assessment of biotin concentrations in individuals taking biotin supplements

 

Investigation of unexpected results from immunoassays that utilize biotin-streptavidin detection methods

 

This test is not useful as a screen for biotinidase deficiency.

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Biotin, S

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 30 days
  Refrigerated  7 days
  Ambient  24 hours

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

≥18 years: ≤0.3 ng/mL

Reference values have not been established for patients who are <18 years of age.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

84591

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BIOTN Biotin, S 1980-2

 

Result ID Test Result Name Result LOINC Value
606867 Biotin, S 1980-2

NY State Approved

Yes

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

Day(s) Performed

Tuesday

Report Available

2 to 7 days